World Health & Population

World Health & Population 10(1) March 2008 : 18-22.doi:10.12927/whp.2008.19581

Squamous Cell Abnormalities in Exfoliated Cells from the Urine of Schistosoma haematobium-Infected Adults in a Rural Fishing Community in Nigeria

O. P. Akinwale, G. C. Oliveira, M. B. Ajayi, D. O. Akande, S. Oyebadejo and K. C. Okereke

Abstract

Schistosoma haematobium infection is endemic in Nigeria, with substantial transmissions in all the states of the federation and a high prevalence rate in schools. Literature has linked bladder cancer, mostly squamous cell type, with long-term S. haematobium infections. The objective of this descriptive study was to screen exfoliated cells in the urine of S. haematobium-infected patients for squamous cell abnormalities through cytopathological examinations. Study participants were drawn from Imala Odo, a community near Oyan Dam in Abeokuta North Local Government Area, Ogun state, Southwest Nigeria. Due to a considerable day-to-day variation of S. haematobium eggs in urine, 3 rounds of 200 ml of urine samples were collected on 3 different days from 32 infected patients and 10 uninfected controls and examined. Cytological preparations of the infected 15 males and 8 females and 10 controls (5 males and 5 females) were screened for squamous cell abnormalities. Severely dysplastic to frankly malignant squamous cells were observed in 1 (3.1%) male and 2 (6.3%) females, while no abnormality was observed in the controls.

 

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