The role of genomic medicine in healthcare is at the tip of the iceberg. Rapid advances in genomics, as demonstrated by the tangible use of gene diagnosis and targeted therapies indicate that the impact of genomics in healthcare is only going to increase. The debate is not "if genomic medicine will impact healthcare" as much as how rapidly it will impact healthcare. However, caution needs to be exercised with respect to three key enablers whose success is critical in order to fully harvest the potential of genomics and successfully integrate genomics in healthcare. These include genomic literacy, privacy and security and IT and the EHR. Health service organizations and healthcare leaders will play a pivotal role in this regard, by beginning to strategize and plan for how they will incorporate genomics into healthcare delivery.