The pursuit of tangible mechanisms and measures to quantify the value-for-money proposition within Canada's healthcare system has become healthcare's own Holy Grail. A critical assessment and analysis of this age-old conundrum, as explored in the lead paper of this issue, forms the basis of this commentary which goes on to challenge readers to consider how healthcare providers can collectively act on the information and research available and begin to leverage investments already made with the goal of affecting real change across the system.