Following a Clinical Adoption workshop held in November 2009, Canadian change management (CM) practitioners came together to develop a common approach for addressing gaps in e-Health CM practices. Through collaborative dialogue, the group, collectively known as the Pan-Canadian CM Network, conducted a current-state analysis and environmental scan of e-Health CM activities and methodologies. As a result, a National CM Framework was developed to promote a best practice model that supports users in their adoption of e-Health solutions. This article will review the six core framework elements required in a CM process to ensure adoption and achieved return on investment, highlighted by examples of practical Canadian applications.