As part of the special focus on nursing leadership and quality improvement, I had the privilege of interviewing Chris Power (CP) chief executive officer of Canadian Patient Safety Institute (CPSI); Michael Villeneuve (MV) chief executive officer of the Canadian Nurses Association (CNA) and Judith Shamian (JS) past president International Council of Nurses (ICN) and former CNA president around their perspectives of our current context and their collective wisdom on key actions for nurse leaders to undertake to advance the quality and safety agenda in Canada and globally.