Late-stage COVID-19 vaccine trial on pause due to possible serious side effect. Here's what that means
2020-09-10 from cbc.ca
A front-running team in the race to develop a COVID-19 vaccine has put its late-stage trial on hold after a reported "unexplained illness" in one of the trial volunteers. Here's what that means for the quick development of a COVID-19 vaccine.
What kind of vaccine trial got put on hold?
The trial was a Phase 3 clinical trial for a vaccine being developed by the University of Oxford and pharmaceutical company AstraZeneca.
It's the largest type of clinical trial, requiring thousands of volunteers, and is the last of three stages of human testing before a vaccine can be approved for use. Its main goals are to:
- Test the efficacy of the vaccine at preventing the disease compared with a placebo
- Get a better idea of possible side effects and how often they happen, including rare side effects that might not show up in smaller trials.
The company is running Phase 3 trials involving thousands of people in the United Kingdom and smaller numbers of people in Brazil and South Africa. It is also recruiting 30,000 people in the United States for its largest study.
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