Imaging is Everything: What The Clinician Needs To Know
The cohort will be recruited from the Humana Health Plan membership represented in three major US markets; Chicago, IL, Louisville, KY and Southern FL. Of the 7300 participants, 6000 will be characterized with respect to their Framingham risk score and various imaging features including carotid and coronary calcification, carotid intimal-medial wall thickness and presence of echogenic lucencies and lower extremity vascular insufficiency as determined by the ankle brachial index. Blood samples will be assayed for putative biochemical risk factors using both an unsupervised proteomic and metabolomic profiling of plasma and targeted assays for particular analytes. In addition, samples will be banked for additional follow on studies. Participants will be followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease (CHD), and stroke; mortality; and for cardiovascular disease interventions. The remaining 1,300 subjects will be evaluated and followed in a similar manner except no imaging studies will be conducted.
The study will be conducted using an innovative infrastructure and method of participant recruitment and enrollment. Mobile laboratories containing the imaging equipment will travel to the three markets included in the study. Participants will be recruited based on claims monitoring to pre-determine eligibility. The baseline examinations of the 7300 participants will occur over a 12 month period. Based on particular findings, (CACS, IMT, ABI and presence of aortic aneurysm), approximately 2,000 participants of the 6,000 imaging cohort will be referred for higher resolution imaging modalities to better characterize their arterial disease. This additional imaging will also be conducted on the mobile laboratories and occur during the same 12 month period. Participants will be contacted every 6 months throughout the 3 year study to assess cardiovascular events, clinical morbidity and mortality, and to obtain additional blood samples.
In summary, A critical issue for the clinician and for society is the following: can imaging technology detect subclinical cardiovascular disease and, as a result, fostering earlier management to promote health and at a lower cost?
Notes to editors:
This study was presented at the ESC Congress 2007 in Vienna.
The European Society of Cardiology (ESC)
The ESC represents nearly 53,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.
The ESC achieves this through a variety of scientific and educational activities including the coordination of: clinical practice guidelines, education courses and initiatives, pan-European surveys on specific disease areas and the ESC Annual Congress, the largest medical meeting in Europe. The ESC also works closely with the European Commission and WHO to improve health policy in the EU.
The ESC comprises 3 Councils, 5 Associations, 19 Working Groups,
50 National Cardiac Societies and an ESC Fellowship Community
(Fellow, FESC; Nurse Fellow, NFESC). For more information on ESC
Initiatives, Congresses and Constituent Bodies see www.escardio.org.
European Society of Cardiology, The European Heart House 2035 Route des Colles, B.P. 179 - Les Templiers, Sophia Antipolis F-06903 France
About the Author(s)
Professor Valentin Fuster, M.D., Ph.D.
Director of Mount Sinai Heart, New York
Be the first to comment on this!
Personal Subscriber? Sign In
Note: Please enter a display name. Your email address will not be publically displayed